Neuropathology

Overview

The Department of Neuropathology is an integral part of the Institute of Pathology. It is staffed by a consultant neuropathologist and head of department (Tibor Hortobágyi, MD, PhD, FRCPath, EFN), a trainee neuropathologist (Tamás Csonka, MD), a full-time (Balázs Murnyák, MSc) and a co-supervised part-time PhD student (Réka Majer, MSc). In addition, Dr Csonka is working on a PhD project parallel with his training.

The Department of Neuropathology has been established in 2011 as an integral part of the Institute of Pathology. Tibor Hortobágyi has been appointed as chairperson in January 2012. He is an internationally recognized expert in diagnostic and academic neuropathology. His colleagues are talented and ambitious young doctors and researchers. Our clinical mission is to provide very high level of diagnostic expertise and care available in neuropathology to patients and families treated at the University of Debrecen Medical & Health Sciences Centre.

Research and Training

Members of the Department of Neuropathology run and support translational research in adult and paediatric brain tumours, neurodegeneration, neuromuscular disease, as well as basic research in cell death and regeneration of the nervous system. There is close link and collaboration with the Neuropathology Laboratory & Brain Bank of the Neurology Department and the Brain Tumour tissue repository at the Department of Neurosurgery.

A key component of our educational mission is to provide graduate medical education in neuropathology for medical and dentistry students. Another major focus is on postgraduate medical education in neuropathology to trainees in Neuropathology, Pathology, Neurology, Neurosurgery and Psychiatry at the University of Debrecen Medical & Health Sciences Centre. Fellows from other institutions wishing to supplement their training in neuropathology are also welcome to do elective rotations. An active lecture series and one-on-one teaching support all of these activities. We welcome trainees and faculty from other institutions who are interested in obtaining advanced experience in neuropathology. Please contact us if you are interested in arranging to visit or rotate through the Department of Neuropathology.

Diagnostic Tests

Diagnostic neuropathology is based on the same principles used for the preparation and evaluation of tissue specimens used in Anatomic Pathology. These include:

  • Gross examination of tissues of the central and peripheral nervous system
  • Preparation of representative tissue sections through tissue fixation, processing, paraffin embedding, and sectioning
  • Use of routine (H&E) and special stains
  • Immunohistochemical and immunofluorescent staining
  • In situhybridization
  • Cytological evaluation of cerebrospinal or cyst fluid
  • Molecular / genetic testing when clinically indicated
  • Electron microscopy

To perform these studies the excellent laboratory facilities at the Institute of Pathology are used.

We offer a wide range of consultation services for outside cases including brain biopsies (both tumours and non-neoplastic diseases), muscle biopsies, autopsy brain and spinal cord examination, forensic neuropathology.

For specific instructions for preparation and submission of cases for consultation contact us at hortobagyi@med.unideb.hu.

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